Study shows diabetes drugs may cause heart failure

September 1, 2008

A number of related drugs for type 2 diabetics may increase their risk of heart failure, a Wake Forest University School of Medicine study finds.

“We strongly recommend restrictions in the use of thiazolidinediones and question the rationale for leaving rosiglitazone on the market,” write Sonal Singh, M.D., M.P.H., assistant professor of internal medicine, and Curt D. Furberg, M.D., Ph.D., professor of public health sciences.

Thiazolidinediones, which regulate users’ blood sugar, appear to double the risk of congestive heart failure among people with type 2 diabetes, study authors Dr. Sonal Singh and Dr. Curt Furberg said in editorial published in the journal Heart.

Drugs in this class include rosiglitazone (Avandia) and pioglitazone (Actos), reports United Press International.

“Safer, cheaper and more effective treatment alternatives are available that do not carry these negative cardiovascular risks in patients with diabetes. The rationale for the use of the thiazolidinediones is unclear.”


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